Biophysics Resource

The Biophysics Resource (BR) is operated by the Structural Biophysics Laboratory (SBL). It is providing access to analytical instrumentation and any required assistance for researchers from the Center for Cancer Research in need of biophysical characterization and examination of systems subject to structural investigations. The facility is managed by Dr. Sergey Tarasov, Staff Scientist.

The BR offers and maintains cutting-edge biophysics technologies in the following areas:

• Circular dichroism spectroscopy for studies of optical activity and conformation of biomacromolecules.

• Steady-state fluorescence spectroscopy for studies of structure and environment of biomacromolecules and mechanism of their interactions.

• Isothermal titration calorimetry for thermodynamic characterization of biomacromolecular interactions.

• Liquid chromatography with mass spectrometry detection for macromolecular mass characterization.

• Multi-angle laser light scattering for determination of macromolecular mass, size and degree of aggregation.

Users must learn to operate the instruments and conduct their own experiments. Users must also abide by the Policy of the BR. Scheduling of the instruments is handled on-line.

Users generally learn to operate the instruments and conduct their own experiments. The BR personnel tutor and train researchers wishing to use the facility and they are available to consult on experimental design/analysis/interpretation or as collaborators in more sophisticated studies.

For further information concerning the various technologies and instrumentation available, please follow the navigation system to view each instrument.

For references, please, see the list of publications and patents.